Identifying Brain Signatures of Obsessive-Compulsive Profiles

(Study funded by an R01 Grant from NIMH, USA)
Site Principal Investigator – Prof. Y.C. Janardhan Reddy
Co-Investigators –  Dr. Janardhanan C. Narayanaswamy; Prof. Ganesan Venkatasubramanian
PI: Prof Helen Blair Simpson, Columbia University Medical Centre, New York


Overall Goals:

The goal of this proposal is to identify reproducible brain signatures associated with cognitive and clinical profiles that are common in individuals with OCD. To accomplish this, 250 unmedicated OCD and 250 healthy control subjects (HCs) at five expert research sites spanning five countries (U.S., Brazil, India, Netherlands, and South Africa) will be examined. Using imaging methods that could ultimately be adapted for clinical use, we will examine multiple brain circuits thought to underlie OCD behaviors, focusing on morphometry (using T1-weighted MRI), structural connectivity (using Diffusion Tensor Imaging [DTI]), and functional connectivity (using resting-state fMRI [rs-fMRI]).

Total Period of Study: 5 years 

Project Staff:

Dr. Karthik S (Senior Resident)

Ms. Madhuri Narayan (Clinical Psychologist)